Cic edizioni internazionali
Journal of Prenatal Medicine

Association between echogenic intracardiac focus in first trimester and biochemical screeningan analysis

Original Article, 14 - 17
doi: 10.11138/jpm/2017.11.1.014
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Introduction: to analyze the relation between presence of EIF in the first trimester, nuchal translucency (NT) and combined biochemical screening.
Methods: a total of 1245 viable low-risk singleton pregnancies was scanned from 11 to 14 weeks gestation. The presence of echogenic intracardiac focus (EIF) in the fetal heart was noted. The ultrasonography was performed by a Fetal Medicine Foundation (FMF) accredited Fetal Medicine Consultant, using recommended guidelines transabdominally and transvaginally when required, by Voluson E6 (GE Healthcare, Kretztechnik, Zipf, Austria). Patients were assessed for the estimated risk of aneuploidy based on their combined first trimester screening report, that included Maternal serum Beta HCG, PAPP-A and nuchal translucency (NT) scan using LifeCycle software.
Nasal bone was not included for calculation of risk. An analysis was then performed between the presence of EIF, combined first trimester screening and NT scan reports.
Results: in 26 patients among the 1245, echo - genic intracardiac focus was identified. Ductus venosus and tricuspid flow was assessed and were found to be normal.The biochemical screening for all patients were screen-negative. NT value of the EIF and combined first trimester screening fetuses were retrospectively analyzed.
Taking this into consideration, all the fetuses identified with EIF, were observed to fall under low-risk category.
Conclusion: presence of EIF in the first trimester does not necessarily mean increased risk for aneuploidy. Larger multivariate studies incorporating ultrasound soft markers identified in first trimester scan in detecting aneuploidy will assist physicians in adequate counseling of mothers and thus help in better guidance and management.